P-selectin expression tracks cerebral atrophy in Mexican-Americans
Background and Purpose. We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure (BP) and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for thirteen mRNA gene-expressio...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00065/full |
| _version_ | 1818133379019702272 |
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| author | Peter eKochunov David eGlahn Elliott eHong Jack L Lancaster Joanne eCurran Matthew eJohnson Anderson eWinkler Henry eHolcomb Jack eKent Braxton eMitchell Valeria eKochunov Rene eOlvera Shelley eCole Thomas eDyer Eric eMoses Harald eGoring Laura eAlmasy Ravi eDuggirala John eBlangero |
| author_facet | Peter eKochunov David eGlahn Elliott eHong Jack L Lancaster Joanne eCurran Matthew eJohnson Anderson eWinkler Henry eHolcomb Jack eKent Braxton eMitchell Valeria eKochunov Rene eOlvera Shelley eCole Thomas eDyer Eric eMoses Harald eGoring Laura eAlmasy Ravi eDuggirala John eBlangero |
| author_sort | Peter eKochunov |
| collection | DOAJ |
| description | Background and Purpose. We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure (BP) and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for thirteen mRNA gene-expression measures from P-selectin and eleven other genes located in 1q24 region and three magnetic resonance imaging (MRI) derived indices of cerebral integrity. Methods. The subject pool consisted of 369 (219F; aged 28-85, average=47.1±12.7 years) normally-aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among thirteen leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter (GM) thickness, fractional anisotropy (FA) of cerebral white matter (WM) and the volume of hyperintensive WM (HWM) lesions Results. From the thirteen gene expressions, significant phenotypic correlations were only found for the P-and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects. Conclusion. This study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy. |
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| format | Article |
| id | doaj.art-abdec554215448feac2c4342b601c3c0 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T08:51:47Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-abdec554215448feac2c4342b601c3c02022-12-22T01:14:00ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-05-01310.3389/fgene.2012.0006521617P-selectin expression tracks cerebral atrophy in Mexican-AmericansPeter eKochunov0David eGlahn1Elliott eHong2Jack L Lancaster3Joanne eCurran4Matthew eJohnson5Anderson eWinkler6Henry eHolcomb7Jack eKent8Braxton eMitchell9Valeria eKochunov10Rene eOlvera11Shelley eCole12Thomas eDyer13Eric eMoses14Harald eGoring15Laura eAlmasy16Ravi eDuggirala17John eBlangero18Maryland Psychiatric Research Center, University of Maryland School of MedicineYale UniversityMaryland Psychiatric Research Center, University of Maryland School of MedicineUniversity of Texas Health Science Center at San AnotnioTexas Biomedical FoundationTexas Biomedical FoundationYale UniversityMaryland Psychiatric Research Center, University of Maryland School of MedicineTexas Biomedical FoundationUniversity of MarylandUniversity of Texas Health Science Center at San AnotnioUniversity of Texas Health Science Center at San AnotnioTexas Biomedical FoundationTexas Biomedical FoundationTexas Biomedical FoundationTexas Biomedical FoundationTexas Biomedical FoundationTexas Biomedical FoundationTexas Biomedical FoundationBackground and Purpose. We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure (BP) and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for thirteen mRNA gene-expression measures from P-selectin and eleven other genes located in 1q24 region and three magnetic resonance imaging (MRI) derived indices of cerebral integrity. Methods. The subject pool consisted of 369 (219F; aged 28-85, average=47.1±12.7 years) normally-aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among thirteen leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter (GM) thickness, fractional anisotropy (FA) of cerebral white matter (WM) and the volume of hyperintensive WM (HWM) lesions Results. From the thirteen gene expressions, significant phenotypic correlations were only found for the P-and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects. Conclusion. This study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00065/fullAgingGene ExpressionGeneticsHypertensionP-SelectinDTI |
| spellingShingle | Peter eKochunov David eGlahn Elliott eHong Jack L Lancaster Joanne eCurran Matthew eJohnson Anderson eWinkler Henry eHolcomb Jack eKent Braxton eMitchell Valeria eKochunov Rene eOlvera Shelley eCole Thomas eDyer Eric eMoses Harald eGoring Laura eAlmasy Ravi eDuggirala John eBlangero P-selectin expression tracks cerebral atrophy in Mexican-Americans Frontiers in Genetics Aging Gene Expression Genetics Hypertension P-Selectin DTI |
| title | P-selectin expression tracks cerebral atrophy in Mexican-Americans |
| title_full | P-selectin expression tracks cerebral atrophy in Mexican-Americans |
| title_fullStr | P-selectin expression tracks cerebral atrophy in Mexican-Americans |
| title_full_unstemmed | P-selectin expression tracks cerebral atrophy in Mexican-Americans |
| title_short | P-selectin expression tracks cerebral atrophy in Mexican-Americans |
| title_sort | p selectin expression tracks cerebral atrophy in mexican americans |
| topic | Aging Gene Expression Genetics Hypertension P-Selectin DTI |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00065/full |
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