Cyy-287, a novel pyrimidine-2,4-diamine derivative, efficiently mitigates inflammatory responses, fibrosis, and lipid synthesis in obesity-induced cardiac and hepatic dysfunction

Cyy-287, a novel pyrimidine-2,4-diamine derivative, efficiently mitigates inflammatory responses, fibrosis, and lipid synthesis in obesity-induced cardiac and hepatic dysfunction

Background Inflammation and metabolic disorders are important factors in the occurrence and development of obesity complications. In this study, we investigated the protective effect and underlying mechanism of a novel pyrimidine-2,4-diamine derivative, Cyy-287, on mice fed a high-fat diet (HFD). Me...

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Bibliographic Details
Main Authors: Jinhuan Ni, Xiaodan Zhang, Huijing Huang, Zefeng Ni, Jianchao Luo, Yunshan Zhong, Min Hui, Zhiguo Liu, Jianchang Qian, Qianwen Zhang
Format: Article
Language:English
Published: PeerJ Inc. 2024-02-01
Series:PeerJ
Subjects:
Cyy-287
Inflammation
Obesity complications
Ventricular remodeling
Hepatic steatosis
NF-kB
Online Access:https://peerj.com/articles/17009.pdf

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https://peerj.com/articles/17009.pdf

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