Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation

Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation

Abstract Background Chromosomal rearrangements are the typical phenomena in cancer genomes causing gene disruptions and fusions, corruption of regulatory elements, damage to chromosome integrity. Among the factors contributing to genomic instability are non-B DNA structures with stem-loops and quadr...

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Bibliographic Details
Main Authors: Kseniia Cheloshkina, Maria Poptsova
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Stem-loops
Quadruplexes
Non-B motifs
DNA secondary structures
Cancer genomes
Cancer mutations
Online Access:http://link.springer.com/article/10.1186/s12885-019-5653-x

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http://link.springer.com/article/10.1186/s12885-019-5653-x

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