Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients

Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients

Cetuximab, an IgG1 EGFR-directed antibody, promotes antibody-dependent cell-mediated cytotoxicity. We hypothesized that single-nucleotide polymorphisms (SNPs) in immune regulatory pathways may predict outcomes in patients with metastatic colorectal cancer treated with cetuximab-based regimens. A tot...

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Bibliographic Details
Main Authors: Nico B. Volz, Diana L. Hanna, Sebastian Stintzing, Wu Zhang, Dongyun Yang, Shu Cao, Yan Ning, Satoshi Matsusaka, Yu Sunakawa, Martin D. Berger, Chiara Cremolini, Fotios Loupakis, Alfredo Falcone, Heinz-Josef Lenz
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
CD24
biomarker
cetuximab
colorectal cancer
single nucleotide polymorphism
Online Access:https://www.mdpi.com/2072-6694/12/10/2947

Internet

https://www.mdpi.com/2072-6694/12/10/2947

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