Multicellular architecture of malignant breast epithelia influences mechanics.

Cell-matrix and cell-cell mechanosensing are important in many cellular processes, particularly for epithelial cells. A crucial question, which remains unexplored, is how the mechanical microenvironment is altered as a result of changes to multicellular tissue structure during cancer progression. In...

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Bibliographic Details
Main Authors: Gautham Venugopalan, David B Camarillo, Kevin D Webster, Clay D Reber, James A Sethian, Valerie M Weaver, Daniel A Fletcher, Hana El-Samad, Chris H Rycroft
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4128597?pdf=render