JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy

JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy

Background: Osteoarthritis (OA) is the most common degenerative joint disease, and its main pathological mechanism is articular cartilage degeneration. The purpose of this study was to investigate the role of mitophagy in the pathogenesis of chondrocyte ferroptosis in OA. Methods: The expressions of...

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Bibliographic Details
Main Authors: Ya Xie, Zhongyang Lv, Weitong Li, JinTao Lin, Wei Sun, Hu Guo, Xiaoyu Jin, Yuan Liu, Ruiyang Jiang, Yuxiang Fei, Rui Wu, Dongquan Shi
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Ferroptosis
JP4-039
Mitophagy
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25000026

Internet

http://www.sciencedirect.com/science/article/pii/S2214031X25000026

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