Association of DNA methyltransferases 3A and 3B polymorphisms, and plasma folate levels with the risk of urothelial carcinoma.

Interindividual genetic variations of human DNA methyltransferases (DNMTs), which involve the methyl donor from the folate-related one-carbon metabolism pathway, are hypothesized as a risk factor for urothelial carcinoma (UC). Therefore, we evaluated the role of gene-environment interaction in UC ca...

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Main Authors: Chi-Jung Chung, Chao-Hsiang Chang, Chiu-Shong Liu, Chi-Ping Huang, Yi-Huei Chang, Ssu-Ning Chien, Ping-Huan Tsai, Hui-An Hsieh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4134234?pdf=render