Genomic alteration of MTAP/CDKN2A predicts sarcomatoid differentiation and poor prognosis and modulates response to immune checkpoint blockade in renal cell carcinoma

Genomic alteration of MTAP/CDKN2A predicts sarcomatoid differentiation and poor prognosis and modulates response to immune checkpoint blockade in renal cell carcinoma

Sarcomatoid differentiation is a highly aggressive pathological characteristic of renal cell carcinoma (RCC) and is characterized by susceptibility to progression and extremely poor prognosis. In this study, we included all genomic alteration events that led to a loss of protein function of MTAP and...

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Bibliographic Details
Main Authors: Wenhao Xu, Aihetaimujiang Anwaier, Wangrui Liu, Gaomeng Wei, Jiaqi Su, Xi Tian, Jing Xia, Yuanyuan Qu, Jianyuan Zhao, Hailiang Zhang, Dingwei Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
renal cell carcinoma
sarcomatoid differentiation
immunotherapy
genomic alteration
MTAP
CDKN2A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.953721/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.953721/full

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