Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes. We hypothesized that this was a compensatory response and that HIF-1α protects β-cells during transplantation. Transplan...

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Bibliographic Details
Main Authors: Rebecca A. Stokes, Kim Cheng, Natasha Deters, Sue Mei Lau, Wayne J. Hawthorne, Philip J. O'connell, Jessica Stolp, Shane Grey, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Frank J. Gonzalez, Jenny E. Gunton
Format: Article
Language:English
Published: SAGE Publishing 2013-02-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X647180

Internet

https://doi.org/10.3727/096368912X647180

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