MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction

MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction

Background: Micheliolide (MCL), which is the active metabolite of parthenolide, has demonstrated promising clinical application potential. However, the effects and underlying mechanisms of MCL on atherosclerosis are still unclear. Method: ApoE−/− mice were fed with high fat diet, with or without MCL...

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Bibliographic Details
Main Authors: Xing Luo, Yuehong Wang, Xinxin Zhu, Yuwu Chen, Biyi Xu, Xiaoxuan Bai, Xiuzhu Weng, Jinmei Xu, Yangyang Tao, Dan Yang, Jie Du, Ying Lv, Shan Zhang, Sining Hu, Ji Li, Haibo Jia
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Atherosclerosis
MCL
Ferroptosis
KEAP1/NRF2
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003889

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http://www.sciencedirect.com/science/article/pii/S2213231723003889

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