Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders

Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders

Liquid–liquid phase separation results in the formation of dynamic biomolecular condensates, also known as membrane-less organelles, that allow for the assembly of functional compartments and higher order structures within cells. Multivalent, reversible interactions between RNA-binding proteins (RBP...

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Bibliographic Details
Main Authors: Aditi Naskar, Asima Nayak, Muthu Raj Salaikumaran, Sonali S. Vishal, Pallavi P. Gopal
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurodegenerative disease
RNA-binding proteins
aggregation
phase separation
biomolecular condensates
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1242925/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1242925/full

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