Narrow Operating Space Based on the Inversion of Latent Structures Model for Glycosylation Process

N-linked glycan distribution plays a significant role in the generation of therapeutic proteins. It is challenging to determine the operating conditions when developing a new biopharmaceutical product with the desired glycan distributions. The glycosylation is a high complex nonlinear system, and it...

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Bibliographic Details
Main Authors: Jing Wang, Xiaolu Chen, Yuhan Nan, Jinglin Zhou, Tonglai Xue
Format: Article
Language:English
Published: IEEE 2020-01-01
Series:IEEE Access
Subjects:
Online Access:https://ieeexplore.ieee.org/document/9225077/