Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo

Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or decelerate osteoarthritis progression are still lacking. Omaveloxolone is a semisynthetic oleanane triterpenoid exerting antioxidative and anti-inflammatory effects. The present study aims to determine wheth...

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Bibliographic Details
Main Authors: Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
omaveloxolone
Nrf2
NF-κB
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.952950/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.952950/full

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