Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome

Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome

Male fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse male reproductive health. The mechanisms of these associations...

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Bibliographic Details
Main Authors: DruAnne L. Maxwell, Oladele A Oluwayiose, Emily Houle, Katherine Roth, Karolina Nowak, Savni Sawant, Amanda L. Paskavitz, Wanqing Liu, Katherine Gurdziel, Michael C. Petriello, J. Richard Pilsner
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Environment International
Subjects:
PFAS
Sperm Epigenetics
Sperm Methylome
Intergenerational
Metabolic Transcriptome
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412024001636

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http://www.sciencedirect.com/science/article/pii/S0160412024001636

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