Solubility Controlling Peptide Tags of Opposite Charges Generate a Bivalent Immune Response Against Dengue ED3 Serotypes 3 and 4

Solubility Controlling Peptide Tags of Opposite Charges Generate a Bivalent Immune Response Against Dengue ED3 Serotypes 3 and 4

We previously demonstrated that a protein’s immunogenicity could be substantially increased by attaching a hydrophobic solubility controlling peptide tag (SCP-tag) producing small sub-visible aggregates. Here, we report the oligomerization of Dengue envelop protein domain 3 (ED3), and consequently,...

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Bibliographic Details
Main Authors: Nafsoon Rahman, Shiho Miura, Mami Okawa, Md. Golam Kibria, Mohammad Monirul Islam, Yutaka Kuroda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
SCP-tag (solubility controlling peptide tag)
electrostatic interaction
sub-visible aggregates
dengue envelope protein domain 3 (ED3)
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.671590/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.671590/full

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