Molecular Basis of Growth Inhibition by Acetate of an Adenylate Cyclase-Deficient Mutant of Corynebacterium glutamicum

Molecular Basis of Growth Inhibition by Acetate of an Adenylate Cyclase-Deficient Mutant of Corynebacterium glutamicum

In Corynebacterium glutamicum, cyclic adenosine monophosphate (cAMP) serves as an effector of the global transcriptional regulator GlxR. Synthesis of cAMP is catalyzed by the membrane-bound adenylate cyclase CyaB. In this study, we investigated the consequences of decreased intracellular cAMP levels...

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Bibliographic Details
Main Authors: Natalie Wolf, Michael Bussmann, Abigail Koch-Koerfges, Nino Katcharava, Julia Schulte, Tino Polen, Johannes Hartl, Julia A. Vorholt, Meike Baumgart, Michael Bott
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
Corynebacterium glutamicum
cAMP
adenylate cyclase
acetate
uncouplers
membrane potential
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00087/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00087/full

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