Chronic oxycodone induces axonal degeneration in rat brain

Chronic oxycodone induces axonal degeneration in rat brain

Abstract Background Chronic opioid therapy for non-malignant pain conditions has significantly increased over the last 15 years. Recently, the correlation between opioid analgesics and alternations in brain structure, such as leukoencephalopathy, axon demyelination, and white matter lesions, has bee...

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Bibliographic Details
Main Authors: Ruping Fan, Lisa M. Schrott, Thomas Arnold, Stephen Snelling, Meghana Rao, Derrel Graham, Angela Cornelius, Nadejda L. Korneeva
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Neuroscience
Subjects:
Axon
Myelin basic protein
Oxycodone
Morphine
Opioid
Nucleus accumbens
Online Access:http://link.springer.com/article/10.1186/s12868-018-0417-0

Internet

http://link.springer.com/article/10.1186/s12868-018-0417-0

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