Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity

Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity

Cancer is one of the important factors threatening human health. Hence, it is essential to create novel potent drugs to treat it. Due to the strong correlation among histone deacetylase1 (HDAC1), speckle-type POZ protein (SPOP) and cancers, dual inhibition of HDAC1 and SPOP may be a promising strate...

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Bibliographic Details
Main Authors: Yingxue Yang, Shutong Chen, Qinghua Wang, Miao-Miao Niu, Yuanqian Qu, Yang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
cancer
histone deacetylase 1
speckle-type POZ protein
dualtargeting inhibitors
structure-based virtual screening
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1208740/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1208740/full

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