Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these effects have not been completely elucidated yet. Here, we showed that Shikonin induces apoptosis and autophagy in A375 cells and i...

Full description

Bibliographic Details
Main Authors: Yongkang Liu, Xing Kang, Geng Niu, Senlin He, Tingting Zhang, Yuwei Bai, Yi Li, Houyan Hao, Chao Chen, Zhexing Shou, Bin Li
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Shikonin
apoptosis
autophagy
ROS
ER stress
p38
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1575229

Internet

https://www.tandfonline.com/doi/10.1080/21691401.2019.1575229

Similar Items