Hereditary Breast Cancer in the Brazilian State of Ceará (The CHANCE Cohort): Higher-Than-Expected Prevalence of Recurrent Germline Pathogenic Variants

Hereditary Breast Cancer in the Brazilian State of Ceará (The CHANCE Cohort): Higher-Than-Expected Prevalence of Recurrent Germline Pathogenic Variants

PurposeThere is a significant lack of epidemiological data on hereditary cancer in Northeast Brazil. This is the largest study on the prevalence and mutational spectrum of cancer predisposition genes conducted in this region and the first in the State of Ceará.MethodsPatients ≥18 years of age that w...

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Bibliographic Details
Main Authors: Ana Carolina Leite Vieira Costa Gifoni, Markus Andret Cavalcante Gifoni, Camila Martins Wotroba, Edenir Inez Palmero, Eduardo Leite Vieira Costa, Wellington dos Santos, Maria Isabel Achatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
hereditary cancer
breast cancer
panel testing
BRCA1/2
PALB2
CHEK2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.932957/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.932957/full

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