Genetic Incorporation of Dansylalanine in Human Ferroportin to Probe the Alternating Access Mechanism of Iron Transport

Genetic Incorporation of Dansylalanine in Human Ferroportin to Probe the Alternating Access Mechanism of Iron Transport

Ferroportin (Fpn), a member of the major facilitator superfamily (MFS) of transporters, is the only known iron exporter found in mammals and plays a crucial role in regulating cellular and systemic iron levels. MFSs take on different conformational states during the transport cycle: inward open, occ...

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Bibliographic Details
Main Authors: Matteo Amadei, Antonella Niro, Maria Rosaria Fullone, Rossella Miele, Fabio Polticelli, Giovanni Musci, Maria Carmela Bonaccorsi di Patti
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
ferroportin
iron
MFS
genetic code expansion
dansylalanine
fluorescence spectroscopy
Online Access:https://www.mdpi.com/1422-0067/24/15/11919

Internet

https://www.mdpi.com/1422-0067/24/15/11919

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