Self-assembly of CXCR4 antagonist peptide–docetaxel conjugates for breast tumor multi-organ metastasis inhibition

Self-assembly of CXCR4 antagonist peptide–docetaxel conjugates for breast tumor multi-organ metastasis inhibition

As a representative chemotherapeutic drug, docetaxel (DTX) has been used for breast cancer treatment for decades. However, the poor solubility of DTX limits its efficacy, and the DTX based therapy increases the metastasis risk due to the upregulation of C–X–C chemokine receptor type 4 (CXCR4) expres...

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Bibliographic Details
Main Authors: Chen Li, Jiayan Lang, Yazhou Wang, Zhaoxia Cheng, Mali Zu, Fenfen Li, Jingyi Sun, Yating Deng, Tianjiao Ji, Guangjun Nie, Ying Zhao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Triple-negative breast cancer
CXCR4
Docetaxel
Drug delivery
Peptide–drug conjugates
Tumor metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001144

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http://www.sciencedirect.com/science/article/pii/S2211383523001144

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