Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration

Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration

Abstract High levels of reactive oxygen species (ROS) lead to progressive deterioration of mitochondrial function, resulting in tissue degeneration. In this study, ROS accumulation induced nucleus pulposus cells (NPCs) senescence is observed in degenerative human and rat intervertebral disc, suggest...

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Bibliographic Details
Main Authors: Yu Shi, Hanwen Li, Dongchuan Chu, Wenzheng Lin, Xinglong Wang, Yin Wu, Ke Li, Huihui Wang, Dandan Li, Zhuobin Xu, Lizeng Gao, Bin Li, Hao Chen
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
cellular senescence
intervertebral disc degeneration
iron sulfide nanoparticle
nanozyme
polysulfides
ROS‐p53‐p21 axis
Online Access:https://doi.org/10.1002/advs.202300988

Internet

https://doi.org/10.1002/advs.202300988

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