Irisin Ameliorate Acute Pancreatitis and Acinar Cell Viability through Modulation of the Unfolded Protein Response (UPR) and PPARγ-PGC1α-FNDC5 Pathways

Irisin Ameliorate Acute Pancreatitis and Acinar Cell Viability through Modulation of the Unfolded Protein Response (UPR) and PPARγ-PGC1α-FNDC5 Pathways

Acute pancreatitis (AP) entails pancreatic inflammation, tissue damage and dysregulated enzyme secretion, including pancreatic lipase (PL). The role of irisin, an anti-inflammatory and anti-apoptotic cytokine, in AP and exocrine pancreatic stress is unclear. We have previously shown that irisin regu...

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Bibliographic Details
Main Authors: Avital Horwitz, Ruth Birk
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Biomolecules
Subjects:
exocrine pancreas
pancreatitis
cerulin
irisin
ER stress
ATF6
Online Access:https://www.mdpi.com/2218-273X/14/6/643

Internet

https://www.mdpi.com/2218-273X/14/6/643

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