Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2...

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Bibliographic Details
Main Authors: Javad Sharifi-Rad, Veronique Seidel, Michalak Izabela, Margalida Monserrat-Mequida, Antoni Sureda, Valeska Ormazabal, Felipe A. Zuniga, Shivaprasad Shetty Mangalpady, Raffaele Pezzani, Alibek Ydyrys, Gulmira Tussupbekova, Miquel Martorell, Daniela Calina, William C. Cho
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cell Communication and Signaling
Subjects:
Phenolic compounds
Cancer
Nrf2
Oxidative stress
Cytotoxicity
Apoptosis
Online Access:https://doi.org/10.1186/s12964-023-01109-0

Internet

https://doi.org/10.1186/s12964-023-01109-0

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