Maternal High Fat Diet-Induced Obesity Modifies Histone Binding and Expression of Oxtr in Offspring Hippocampus in a Sex-Specific Manner

Maternal High Fat Diet-Induced Obesity Modifies Histone Binding and Expression of Oxtr in Offspring Hippocampus in a Sex-Specific Manner

Maternal obesity during pregnancy increases risk for neurodevelopmental disorders in offspring, although the underlying mechanisms remain unclear. Epigenetic deregulation associates with many neurodevelopmental disorders, and recent evidence indicates that maternal nutritional status can alter chrom...

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Bibliographic Details
Main Authors: Kelly A. Glendining, Christine L. Jasoni
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
developmental programming
maternal nutrition
neurodevelopment
epigenetic modification
H3K9Ac
H3K9me3
oxytocin receptor
obesity
Online Access:http://www.mdpi.com/1422-0067/20/2/329

Internet

http://www.mdpi.com/1422-0067/20/2/329

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