Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics

Here, the authors investigate the maturation of Okazaki fragments with human proteins and reveal that initiator RNA removal occurs non-processively and slowly suggesting that additional pathways might exist to accelerate RNA removal in cells.

Bibliographic Details
Main Authors: Vlad-Stefan Raducanu, Muhammad Tehseen, Amani Al-Amodi, Luay I. Joudeh, Alfredo De Biasio, Samir M. Hamdan
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34751-2