Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics
Here, the authors investigate the maturation of Okazaki fragments with human proteins and reveal that initiator RNA removal occurs non-processively and slowly suggesting that additional pathways might exist to accelerate RNA removal in cells.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34751-2 |
| _version_ | 1828094229135491072 |
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| author | Vlad-Stefan Raducanu Muhammad Tehseen Amani Al-Amodi Luay I. Joudeh Alfredo De Biasio Samir M. Hamdan |
| author_facet | Vlad-Stefan Raducanu Muhammad Tehseen Amani Al-Amodi Luay I. Joudeh Alfredo De Biasio Samir M. Hamdan |
| author_sort | Vlad-Stefan Raducanu |
| collection | DOAJ |
| description | Here, the authors investigate the maturation of Okazaki fragments with human proteins and reveal that initiator RNA removal occurs non-processively and slowly suggesting that additional pathways might exist to accelerate RNA removal in cells. |
| first_indexed | 2024-04-11T06:57:04Z |
| format | Article |
| id | doaj.art-ac250a7a603b45faab1879d0f65dbec0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T06:57:04Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ac250a7a603b45faab1879d0f65dbec02022-12-22T04:39:01ZengNature PortfolioNature Communications2041-17232022-11-0113111710.1038/s41467-022-34751-2Mechanistic investigation of human maturation of Okazaki fragments reveals slow kineticsVlad-Stefan Raducanu0Muhammad Tehseen1Amani Al-Amodi2Luay I. Joudeh3Alfredo De Biasio4Samir M. Hamdan5Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and TechnologyBioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and TechnologyBioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and TechnologyBioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and TechnologyBioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and TechnologyBioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and TechnologyHere, the authors investigate the maturation of Okazaki fragments with human proteins and reveal that initiator RNA removal occurs non-processively and slowly suggesting that additional pathways might exist to accelerate RNA removal in cells.https://doi.org/10.1038/s41467-022-34751-2 |
| spellingShingle | Vlad-Stefan Raducanu Muhammad Tehseen Amani Al-Amodi Luay I. Joudeh Alfredo De Biasio Samir M. Hamdan Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics Nature Communications |
| title | Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics |
| title_full | Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics |
| title_fullStr | Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics |
| title_full_unstemmed | Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics |
| title_short | Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics |
| title_sort | mechanistic investigation of human maturation of okazaki fragments reveals slow kinetics |
| url | https://doi.org/10.1038/s41467-022-34751-2 |
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