mRNA vaccination drives differential mucosal neutralizing antibody profiles in naïve and SARS-CoV-2 previously-infected individuals

mRNA vaccination drives differential mucosal neutralizing antibody profiles in naïve and SARS-CoV-2 previously-infected individuals

Two doses of BNT162b2 mRNA vaccine induces a strong systemic SARS-CoV-2 specific humoral response. However, SARS-CoV-2 airborne transmission makes mucosal immune response a crucial first line of defense. Therefore, we characterized SARS-CoV-2-specific IgG responses induced by BNT162b2 vaccine, as we...

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Detalhes bibliográficos
Main Authors: Stephanie Longet, Alexander Hargreaves, Saoirse Healy, Rebecca Brown, Hailey R. Hornsby, Naomi Meardon, Tom Tipton, Eleanor Barnes, Susanna Dunachie, Christopher J. A. Duncan, Paul Klenerman, Alex Richter, Lance Turtle, Thushan I. de Silva, Miles W. Carroll
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2022-09-01
Colecção:Frontiers in Immunology
Assuntos:
antibody responses
mucosal immunity
SARS-CoV-2
mRNA vaccination
neutralizing responses
ACE2 inhibition
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.953949/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.953949/full

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