Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins.

Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins.

The long-term repopulating hematopoietic stem cell (HSC) population can self-renew in vivo, support hematopoiesis for the lifetime of the individual, and is of critical importance in the context of bone marrow stem cell transplantation. The mechanisms that regulate the expansion of HSCs in vivo and...

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Bibliographic Details
Main Authors: Gregory A Bird, Avital Polsky, Patricia Estes, Teri Hanlon, Haley Hamilton, John J Morton, Jonathan Gutman, Antonio Jimeno, Brian C Turner, Yosef Refaeli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4149411?pdf=render

Internet

http://europepmc.org/articles/PMC4149411?pdf=render

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