Antibiotic‐mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Antibiotic‐mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Abstract Recent epidemiological evidence suggests that exposure to antibiotics in early‐to‐middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investig...

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Bibliographic Details
Main Authors: Kamaljeet Kaur, Arpit Saxena, Irina Debnath, Jacqueline L. O'Brien, Nadim J. Ajami, Thomas A. Auchtung, Joseph F. Petrosino, Alexander‐Jacques Sougiannis, Sarah Depaep, Alexander Chumanevich, Phani M. Gummadidala, Mayomi H. Omebeyinje, Sourav Banerjee, Ioulia Chatzistamou, Paramita Chakraborty, Raja Fayad, Franklin G. Berger, James A. Carson, Anindya Chanda
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Cancer Medicine
Subjects:
Antibiotics
Colorectal cancer
Goblet cells
Microbiome
Online Access:https://doi.org/10.1002/cam4.1460

Internet

https://doi.org/10.1002/cam4.1460

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