Understanding the structure–property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions

Understanding the structure–property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions

ABSTRACTDevelopment of novel bispecific antibody (bsAb) platforms offers unprecedented opportunities for a wide variety of therapeutic applications. However, the expression and manufacturing of bsAbs with desired structures can be challenging. Owing to the uniqueness of each bsAb platform, more comp...

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Bibliographic Details
Main Authors: Bo Zhao, Yunlong Zhao, Stephanie Adaniya, Yue Fu, Youmi Moon, Justin Heftel, Shuzhen Chen, Hui Xiao, Ning Li
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Bispecific antibody
Fc conformation
site-specific substitution
HDX-MS
methionine oxidation
thermal stability
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2228006

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2228006

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