Biosensor-guided detection of outer membrane-specific antimicrobial activity against Pseudomonas aeruginosa from fungal cultures and medicinal plant extracts

Biosensor-guided detection of outer membrane-specific antimicrobial activity against Pseudomonas aeruginosa from fungal cultures and medicinal plant extracts

ABSTRACT Pseudomonas aeruginosa responds to sub-lethal antimicrobial exposure by inducing the expression of lipopolysaccharide (LPS) surface modifications that mask antibiotic binding sites and contribute to repair and resistance of the outer membrane (OM). We exploit these membrane damage-responsiv...

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Bibliographic Details
Main Authors: Steve Shideler, Tyson Bookout, Azka Qasim, Lauren Bowron, Qiaolian Wu, Kangmin Duan, Roland Treu, Shauna Reckseidler-Zenteno, Shawn Lewenza
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas
biosensors
outer membrane damage
polymyxin resistance
antibiotic discovery
natural products
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01536-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01536-23

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