A new parallel, rapid, and green Knoevenagel condensation catalyzed by in-situ generated carbonic acid (CO2 (g) in water): Application to intermediate of AMG 837
This work demonstrates the first-ever use of carbonic acid from sparkling water and the one generated in-situ from dry ice for efficient Knoevenagel condensation. Various aldehydes reacted well with active methylenes in a shorter reaction time in environmentally-friendly ethanol: water (1:1) mixture...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623000723 |