TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2

TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2

Cardiac involvement is one of the most important manifestations of the multisystemic phenotype of patients affected by myotonic dystrophy (DM) and represents the second cause of premature death. Molecular mechanisms responsible for DM cardiac defects are still unclear; however, missplicing of the ca...

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Bibliographic Details
Main Authors: Francesca Bosè, Laura Valentina Renna, Barbara Fossati, Giovanni Arpa, Valentina Labate, Valentina Milani, Annalisa Botta, Emanuele Micaglio, Giovanni Meola, Rosanna Cardani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neurology
Subjects:
myotonic dystrophies
cardiac troponin T
cardiac involvement
skeletal muscle
alternative splicing
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00992/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00992/full

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