Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis from sputum samples

Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis from sputum samples

ABSTRACT Tuberculosis (TB) remains a significant global health challenge, exacerbated by the emergence of drug-resistant strains, such as those resistant to pyrazinamide (PZA). The current scarcity of affordable and precise quantitative diagnostic tests for PZA resistance underscores the urgent need...

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Bibliographic Details
Main Authors: Emily Toscano-Guerra, Roberto Alcántara, Katherine Lozano Untiveros, Robert Gilman, Louis Grandjean, Mirko Zimic, Patricia Sheen
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
Tuberculosis
pyrazinamide
pyrazinoic acid
resistance
MODS-Wayne
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00471-24

Internet

https://journals.asm.org/doi/10.1128/spectrum.00471-24

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