Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway

Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway

Originally discovered in <i>C. elegans</i>, LIN28 is an evolutionarily conserved zinc finger RNA-binding protein (RBP) that post-transcriptionally regulates genes involved in developmental timing, stem cell programming, and oncogenesis. LIN28 acts via two distinct mechanisms. It blocks t...

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Bibliographic Details
Main Authors: Greater Kayode Oyejobi, Xiaodan Yan, Piotr Sliz, Longfei Wang
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
LIN28
let-7
miRNA
small-molecule inhibitor
oncogene
gene therapy
Online Access:https://www.mdpi.com/1422-0067/25/7/3585

Internet

https://www.mdpi.com/1422-0067/25/7/3585

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