NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB

NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB

Abstract Background NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inflammasome inhibitor, MCC950, to investigate whether it inhibited liver fibrosis, and explored the preliminary molecular mechanism. Meth...

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Bibliographic Details
Main Authors: Wen-Juan Zhang, Zheng-Ming Fang, Wen-Qi Liu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Parasites & Vectors
Subjects:
NLRP3 inflammasome
Liver fibrosis
Schistosoma japonicum
Kupffer cells
Online Access:http://link.springer.com/article/10.1186/s13071-018-3223-8

Internet

http://link.springer.com/article/10.1186/s13071-018-3223-8

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