Topical Use of Angiopoietin-like Protein 2 RNAi-loaded Lipid Nanoparticles Suppresses Corneal Neovascularization

Topical Use of Angiopoietin-like Protein 2 RNAi-loaded Lipid Nanoparticles Suppresses Corneal Neovascularization

Corneal neovascularization (CNV) is a sight-threatening condition that is encountered in various inflammatory settings including chemical injury. We recently confirmed that angiopoietin-like protein 2 (ANGPTL2) is a potent angiogenic and proinflammatory factor in the cornea, and we have produced a s...

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Bibliographic Details
Main Authors: Yukako Taketani, Tomohiko Usui, Tetsuya Toyono, Nobuyuki Shima, Seiichi Yokoo, Mikiko Kimakura, Satoru Yamagami, Shinichiro Ohno, Risako Onodera, Kohei Tahara, Hirofumi Takeuchi, Masahiko Kuroda
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
angiogenesis
cornea
lipid nanoparticles
topical RNAi eye drops
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300331

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http://www.sciencedirect.com/science/article/pii/S2162253117300331

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