Anti‐β7 integrin treatment impedes the recruitment on non‐classical monocytes to the gut and delays macrophage‐mediated intestinal wound healing

Anti‐β7 integrin treatment impedes the recruitment on non‐classical monocytes to the gut and delays macrophage‐mediated intestinal wound healing

Abstract Background Closing mucosal defects to reach mucosal healing is an important goal of therapy in inflammatory bowel disease (IBD). Among other cells, monocyte‐derived macrophages are centrally involved in such intestinal wound healing. We had previously demonstrated that the anti‐α4β7 integri...

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Bibliographic Details
Main Authors: Katrin Sommer, Karin Heidbreder, Lucas Kreiss, Mark Dedden, Eva‐Maria Paap, Maximilian Wiendl, Emily Becker, Raja Atreya, Tanja M. Müller, Imke Atreya, Maximilian Waldner, Sebastian Schürmann, Oliver Friedrich, Markus F. Neurath, Sebastian Zundler
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Clinical and Translational Medicine
Subjects:
etrolizumab
gut homing
intestinal wound healing
monocytes
vedolizumab
Online Access:https://doi.org/10.1002/ctm2.1233

Internet

https://doi.org/10.1002/ctm2.1233

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