Salsalate reduces atherosclerosis through AMPKβ1 in mice

Salsalate reduces atherosclerosis through AMPKβ1 in mice

Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and cholesterol in the liver through phosphorylation of acetyl-...

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Bibliographic Details
Main Authors: Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Sterol synthesis
Lipogenesis
Macrophage
Proliferation
Salicylate
Aspirin
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782100168X

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http://www.sciencedirect.com/science/article/pii/S221287782100168X

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