Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4‐mediated Ferroptosis in Colorectal Cancer

Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4‐mediated Ferroptosis in Colorectal Cancer

Abstract Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer (CRC); however, frequent drug resistance limits its therapeutic efficacy in patients. Here, this work identifies cyclin‐dependent kinase 1 (CDK1) as a critical contributor to oxaliplatin resistance v...

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Bibliographic Details
Main Authors: Kaixuan Zeng, Weihao Li, Yue Wang, Zifei Zhang, Linjie Zhang, Weili Zhang, Yue Xing, Chi Zhou
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
ACSL4
CDK1
colorectal cancer
ferroptosis
oxaliplatin resistance
Online Access:https://doi.org/10.1002/advs.202301088

Internet

https://doi.org/10.1002/advs.202301088

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