Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo

Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo

IntroductionMucosal-associated invariant T (MAIT) cells are a population of innate-like T cells, which mediate host immunity to microbial infection by recognizing metabolite antigens derived from microbial riboflavin synthesis presented by the MHC-I-related protein 1 (MR1). Namely, the potent MAIT c...

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Bibliographic Details
Main Authors: Adam G. Nelson, Huimeng Wang, Phoebe M. Dewar, Eleanor M. Eddy, Songyi Li, Xin Yi Lim, Timothy Patton, Yuchen Zhou, Troi J. Pediongco, Lucy J. Meehan, Bronwyn S. Meehan, Jeffrey Y. W. Mak, David P. Fairlie, Andrew W. Stent, Lars Kjer-Nielsen, James McCluskey, Sidonia B. G. Eckle, Alexandra J. Corbett, Michael N. T. Souter, Zhenjun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
MAIT cells
5-amino-6-D-ribitylaminouracil (5-A-RU)
MAIT cell boosting
mouse model
CpG
IL-23
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1109759/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1109759/full

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