Upregulated microRNA-125b-5p in patients with asthma-COPD overlap mediates oxidative stress and late apoptosis via targeting IL6R/TRIAP1 signaling

Upregulated microRNA-125b-5p in patients with asthma-COPD overlap mediates oxidative stress and late apoptosis via targeting IL6R/TRIAP1 signaling

Abstract Background Among patients with chronic obstructive pulmonary disease (COPD), some have features of both asthma and COPD—a condition categorized as asthma-COPD overlap (ACO). Our aim was to determine whether asthma- or COPD-related microRNAs (miRNAs) play a role in the pathogenesis of ACO. M...

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Bibliographic Details
Main Authors: Yu-Ping Chang, Yi-Hsuan Tsai, Yu-Mu Chen, Kuo-Tung Huang, Chiu-Ping Lee, Po-Yuan Hsu, Hung-Chen Chen, Meng-Chih Lin, Yung-Che Chen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Respiratory Research
Subjects:
Asthma-COPD overlap
Interleukin 6 receptor
miR-125b-5p
TP53-regulated inhibitor of apoptosis 1
Online Access:https://doi.org/10.1186/s12931-024-02703-7

Internet

https://doi.org/10.1186/s12931-024-02703-7

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