High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Abstract Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML). While extended interval dosing (EID) of NTZ reduc...

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Bibliographic Details
Main Authors: Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Neuroinflammation
Subjects:
Blood–brain barrier
Brain microvascular endothelial cells
Central nervous system
Extended interval dosing
Intercellular adhesion molecule-1
Multiple sclerosis
Online Access:https://doi.org/10.1186/s12974-023-02797-8

Internet

https://doi.org/10.1186/s12974-023-02797-8

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