Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway

Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway

Mitophagy preserves microvascular structure and function during myocardial ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect mitochondria. We explored whether empagliflozin could reduce cardiac microvascular I/R injury by enhancing mitophagy. In mice, I/R inju...

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Bibliographic Details
Main Authors: Chen Cai, Zhongzhou Guo, Xing Chang, Ziying Li, Feng Wu, Jing He, Tiantian Cao, Kangrong Wang, Nengxian Shi, Hao Zhou, Sam Toan, David Muid, Ying Tan
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Redox Biology
Subjects:
Empagliflozin
Cardiac microvascular I/R injury
AMPKα1/ULK1 pathway
FUNDC1-Dependent mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200060X

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http://www.sciencedirect.com/science/article/pii/S221323172200060X

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