Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation

Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation

Oligopeptidase B (OPB) is the least studied group from the prolyl oligopeptidase family. OPBs are found in bacteria and parasitic protozoa and represent pathogenesis factors of the corresponding infections. OPBs consist of two domains connected by a hinge region and have the characteristics of confo...

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Bibliographic Details
Main Authors: Vladimir V. Britikov, Vladimir I. Timofeev, Dmitry E. Petrenko, Elena V. Britikova, Alena Y. Nikolaeva, Anna V. Vlaskina, Konstantin M. Boyko, Anna G. Mikhailova, Tatiana V. Rakitina
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Crystals
Subjects:
crystal structure
prolyl oligopeptidase
oligopeptidase B
intermediate state
hinge region
X-ray diffraction analysis
Online Access:https://www.mdpi.com/2073-4352/12/5/712

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https://www.mdpi.com/2073-4352/12/5/712

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