Encapsulation of (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3 yl)ethylidene)benzohydrazide (7-diEAHC) in β-cyclodextrins: Optimized synthesis of 7-diEACH and in silico ADME profiling, physical stability, antioxidant properties of encapsulated 7-diEAHC and bioavailability in rats

Encapsulation of (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3 yl)ethylidene)benzohydrazide (7-diEAHC) in β-cyclodextrins: Optimized synthesis of 7-diEACH and in silico ADME profiling, physical stability, antioxidant properties of encapsulated 7-diEAHC and bioavailability in rats

The β-cyclodextrins (β-CD) as supramolecular have extremely attractive pharmaceutical applications. This study focused on the effects of macrocyclic systems complexation on stability, antioxidant activities, and bioavailability of the optimized synthesis coumarin incorporating hydrazone moiety. Opti...

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Bibliographic Details
Main Authors: Emna Khdhiri, Souhir Abid, Khaled Athmouni, Majdi Abid, Habib Ayadi, Houcine Ammar, Ludovic Paquin, Jean-Pierre Bazureau
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Hydrazone coumarin
β-Cyclodextrins
Optimization
ADME parameters
Micro-encapsulation
Bio-assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622004003

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http://www.sciencedirect.com/science/article/pii/S2211715622004003

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