A Genome-Wide Screen in Macrophages Defines Host Genes Regulating the Uptake of Mycobacterium abscessus

A Genome-Wide Screen in Macrophages Defines Host Genes Regulating the Uptake of Mycobacterium abscessus

ABSTRACT The interactions between a host cell and a pathogen can dictate disease outcomes and are important targets for host-directed therapies. Mycobacterium abscessus (Mab) is a highly antibiotic resistant, rapidly growing nontuberculous mycobacterium that infects patients with chronic lung diseas...

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Bibliographic Details
Main Authors: Haleigh N. Gilliland, Olivia K. Beckman, Andrew J. Olive
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mSphere
Subjects:
CRISPR-Cas9
functional genetics
Mycobacterium
Mycobacterium abscessus
macrophages
phagocytosis
Online Access:https://journals.asm.org/doi/10.1128/msphere.00663-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00663-22

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