High dose rifampicin kills persisters, shortens treatment duration and reduces relapse rate in vitro and in vivo

High dose rifampicin kills persisters, shortens treatment duration and reduces relapse rate in vitro and in vivo

Although high-dose rifampicin holds promise for improving tuberculosis control by potentially shortening treatment duration, these effects attributed to eradication of persistent bacteria are unclear. The presence of persistent M. tuberculosis was examined using resuscitation promoting factors (RPF)...

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Bibliographic Details
Main Authors: Yanmin eHu, Alexander eLiu, Fatima eOrtega-Muro, Laura eAlameda-Martin, Denis eMitchison, Anthony eCoates
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
Persistence
rifampicin
mouse model
resuscitation promoting factors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00641/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00641/full

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